Manufacturer: Sanofi Aventis, Synthelabo
Pharmaceutical name: Pack: 1 tab (150 tabs 400 mg)
Indications and Usage for Trental
Trental is indicated for the treatment of patients with intermittent claudication on the basis of chronic occlusive arterial disease of the limbs. Trental can improve function and symptoms but is not intended to replace more definitive therapy, such as surgical bypass, or removal of arterial obstructions when treating peripheral vascular disease.
Dosage And Administration
The usual dosage of Trental (pentoxifylline) in extended-release tablet form is one tablet (400 mg) three times a day with meals.
While the effect of Trental (pentoxifylline) may be seen within 2 to 4 weeks, it is recommended that treatment be continued for at least 8 weeks. Efficacy has been demonstrated in double-blind clinical studies of 6 months duration.
Digestive and central nervous system side effects are dose related. If patients develop these effects it is recommended that the dosage be lowered to one tablet twice a day (800 mg/day). If side effects persist at this lower dosage, the administration of Trental (pentoxifylline) should be discontinued.
Side effects
If you experience any of the following serious side effects, stop taking pentoxifylline and seek medical attention:
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an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
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chest pain or an irregular heartbeat;
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severe dizziness, headache, nosebleeds, or blurred vision;
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nausea or vomiting; or
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swollen feet or ankles.
