Analgin

Analgin is a medicine of the pyrazolone group, possessing hard analgesic and antipyretic effects and moderate anti-inflammatory activity. Blocking of the synthesis of endogenous pyrogens - prostaglandins D and E - is the cause for the antipyretic activity and also for the analgesic action of this drug. The decrease of the prostaglandis production in the periphery (and respective decrease of nerve endings sensitivity) plays a relatively smaller role. In contrast to the other nonnarcotic analgesic drugs, Analgin stimulates the release of β-endorphins, explaining its activity in cases of visceral pain. Analgin has a slight spasmolytic activity on the smooth muscle cells of the biliary and urinary tracts and also on the muscle of the uterus.

Indications:
Analgin tablets are used for the treatment of pains of different origin and variable intensity: toothache, headache, arthralgia, neuralgia, myositis, mild to moderate visceral pain, high fever, not responding to other drugs.

Contraindications and cautions:
Hypersensitivity to metamizole and other pyrazolone derivatives, acute hepatic porphyria, inborn glucose-6-phosphate dehydrogenase deficiency, severe renal or hepatic diseases, blood diseases (such as aplastic anemia, leucopenia and agranulocytosis), pregnancy (the first and the last trimester). Parenteral administration of Analgin is contraindicated in under 1 year-old children.

Analgin is used with increased caution in patients with a history for hypersensitivity to foods and drugs (particularly to analgesic and non-steroidal anti-inflammatory agents) and also in patients suffering from bronchial asthma, Quincke's edema, chronic pulmonary infections. In patients with hypotension and unstable blood pressure, Analgin should not be used parentarally. If Analgin application is quite necessary, the blood pressure and the heart rate should be monitored. In cases of prolonged Analgin treatment, regular blood count checks are necessary (differential count of the white blood cells). The high Analgin doses can influence unfavourably the active attention. Because of this in these cases driving and working with machines are not advised.

Adverse effects:
The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.

After prolonged administration very rarely can be observed agranulocytosis, leucopenia and thrombocytopenia, proteinuria, interstitial nephritis. In sensitive patients rashes, urticaria, Quincke's edema, asthmatic attacks, and very rarely anaphylactic shock are possible.

Interactions:
Tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine.

Analgin potentiates the analgesic and antipyretic action of the nonsteroidal antiinflammatory drugs. The Analgin effects are potentiated by the tricyclic antidepressants, oral contraceptive agents, allopurinol, alcohol. Analgin decreases the activity of the coumarin anticoagulants and plasma levels of cyclosporin. The enzyme inductors (barbiturates, glutethimide, phenylbutazone) attenuate the Analgin effects. Analgin potentiates the effects of the drugs possessing CNS depressant activity. Concurrent administration with chlorpromazine is related with a risk of severe hypothermia. Analgin can be used in combination with buscolysin, atropin, codein.